Panama's location as a bridge between South, Central & Northern America has left it as a natural location for drug traffickers to ship their loads. The trade agreements therein also highly prove lucrative for businesses worldwide, and narcotics organizations are no different in this regard.
Using Panama's free trade agreements and taking advantage of their corrupt officials they are known to use Panama as a base to launder money.
Similarly to Nicaragua north of the territory, Panama is also home to several 'Tumbadores', essentially criminal groups which prey upon drug shipments. Stealing them from their rightful owners and selling them to rival groups or back to the original organization under duress. A high stakes game with frequently gruesome results.